Wainwright, 39, will work with play-by-play announcer Adam Amin, analyst AJ Pierzynski and reporter Tom Verducci.
Wainwright began his professional career with the Braves, who traded him to St. Louis in December 2003. He made his major league debut in 2005 and has gone 167-98 with a 3.38 ERA in his big league career.
The 39-year-old right-hander knows something about the postseason, too. He has pitched in 28 playoff games with a 4-5 record, 2.89 ERA and four saves, including the last out of the deciding game of the 2006 World Series against Detroit.