1 p.m. ET | FOX
Matchup rating: 44.8 | Spread: LAR -7 (45.5)
What to watch for: All eyes will be on new Washington starting quarterback Kyle Allen‘s performance. Washington benched Dwayne Haskins Jr. after four lackluster games, with concerns about his maturation as an NFL quarterback. Allen knows the offense better, having played under Ron Rivera with the Panthers, and the coaches are hoping that he makes the plays they feel have been available. But Allen has to take care of the ball; he turned it over 15 times in his last seven starts with Carolina in 2019. That includes three lost fumbles, so he must do a better job against a team that ranks fifth in the NFL with 12 sacks. — John Keim
Bold prediction: Rams running back Darrell Henderson Jr., who was quiet in Week 3, will break out for the second 100-yard rushing game of his career. The Rams are coming off an uninspiring offensive performance against the Giants, so watch for them to establish their run game early against a Washington team that’s allowing an average of 129.8 rushing yards per game. — Lindsey Thiry
Stat to know: Washington is just 33.3% on third down this season, the worst mark in the NFL. And that’s actually an improvement from 2019, when it was 29.1% (also last).
What to know for fantasy: Washington running back Antonio Gibson has a rushing score and at least 12 touches in three straight games. During those three games, his 1.16 PPR points per touch ranks eighth among qualifiers — ahead of Dalvin Cook among others. See Week 5 rankings.
Betting nugget: The Rams are 6-2 ATS as a road favorite of at least six points under Sean McVay. Read more.
Thiry’s pick: Rams 32, Washington 17
Keim’s pick: Rams 24, Washington 23
FPI prediction: LAR, 70.9% (by an average of 7.6 points)
Matchup must-reads: How Ramsey makes the Rams better: ‘His swag is contagious’ … Haskins’ benching a signal his NFL future isn’t in Washington … Rams are running their way back into contention … Ron Rivera draws on lifetime of lessons to face cancer, chaos in Washington … Rams’ Ramsey, Giants’ Tate trade punches after game